The Carman Li laboratory ( in the Department of Cancer Biology at the University of Pennsylvania is hiring a Research Specialist A/B. The Li lab studies unexplored mechanisms and therapeutic opportunities of hereditary cancers, particularly BRCA1/2 breast cancers, with the ultimate goal of improving patient outcomes. We use advanced methodologies, including genetically engineered mouse models, organoid cultures, patient samples, and single-cell omics. This is an excellent opportunity to learn a wide array of in vivo, in vitro, and molecular techniques, contribute to cutting-edge research, and help advance the frontiers of cancer biology. The Li lab values a supportive and collaborative environment. Former trainees mentored by Dr. Li have earned publication authorship and successfully transitioned to graduate/medical schools and industry positions. Successful candidates will have a strong background in biology, be highly motivated, and have excellent organizational skills. Responsibilities include supporting daily lab operations and contributing to research projects. Position is contingent upon continued grant funding. Job Responsibilities: Assist lab operations (including ordering, inventory, organization, and maintenance of equipment and reagents). Contribute to research projects (with supervision for RS-A or independently for RS-B), including: Mouse Work (e.g. colony maintenance, experiments, sample collection and analyses), 2D cell and 3D organoid cultures, Molecular, cell, and tissue analyses (DNA cloning, CRISPR/RNAi gene perturbation, DNA/RNA/protein analysis, flow cytometry, histology). The RS-B position will also assist with training lab members, including students and postdocs. Other duties and responsibilities as assigned. Qualifications: For RS-A: Bachelor of Science and 0 to 1 years of experience or an equivalent combination of education and experience in relevant areas is required. For RS-B: Bachelor of Science and 1 to 3 years of experience or an equivalent combination of education and experience in relevant areas is required. Experience in one or more of the following is required: mouse models of cancer, cell/organoid culture, lab management. Highly motivated, have a good work ethic, and work independently and as a team. Follow protocols with attention to detail. Produce accurate and high-quality work. Think creatively to solve problems. Excellent skills in communication, organization, and time management.
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